Why the study?
How do epigenetic modifications influence the development of different heart failure phenotypes?
How do epigenetic modifications influence the development of different heart failure phenotypes?
This commentary highlights the role of epigenetic modifications in the pathogenesis and phenotypic differentiation of heart failure.
Answers are grounded in this paper and cite their sources.
Epigenetic insights may guide HF phenotype research; hypothesis-generating and should not yet change practice.
Heart failure (HF) remains a leading cause of death in patient population with known cardiovascular disease. Within last two decades there are evidences regarding decline to determine newel cases with HF with reduced ejection fraction (HFrEF) in developed countries, whereas the frequency of newly-diagnosed HF with preserved ejection fraction (HFpEF) exhibits dramatically rise. Epigenetic modification is considered a modification of the non-DNA sequences related heritable changes in gene expression of target cells. Epigenetic modifications affect several molecular mechanisms, i.e., DNA methylation and deactylation, ATP-dependent chromatin remodeling, histone modifications, and microRNA regulation. The short commentary is clarified the implication of epigenetic modifications in development of different HF phenotypes.
No takes yet. Share an insight, caveat, or question.
Alexander Е. Berezin (2016) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: