What question did this study set out to answer?

Investigate the role of cell-extracellular matrix interactions mediated by beta-1 integrins during in vivo dorsal aortic vasculogenesis.

January 1, 1992Developmental DynamicsOpen Access

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

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Authors

CDChristopher J. DrakeMedical University of South Carolina LDLynn DavisUniversité Laval CLCharles D. LittleUnited States Army Corps of Engineers

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Implication

In vivo experimental study reveals that neutralizing beta-1 integrins halts aortic tubulogenesis in avian embryos, indicating an essential role for cell-matrix interactions in vessel lumen formation.

Key Points

Investigate the role of cell-extracellular matrix interactions mediated by beta-1 integrins during in vivo dorsal aortic vasculogenesis.
Injected the CSAT monoclonal antibody (which neutralizes avian beta-1 integrin ligand-binding activity) or control reagents into quail embryos during active vasculogenesis (4–10 somite stage).
CSAT injection arrested vasculogenesis during the rearrangement of slender cord-like angioblast assemblies into tubular structures.
Aortic primordia located near the site of antibody injection failed to develop into patent vessels, unlike control-treated embryos.

Cite This Study

Drake et al. (1992) studied this question.

synapsesocial.com/papers/6a77fcf3a0847c3df1ecb482 https://doi.org/10.1002/aja.1001930111

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Implication

In vivo experimental study reveals that neutralizing beta-1 integrins halts aortic tubulogenesis in avian embryos, indicating an essential role for cell-matrix interactions in vessel lumen formation.

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

Antibodies to β₁‐integrins cause alterations of aortic vasculogenesis, in vivo

Discussion

Member takes

Implication

Key Points

Cite This Study

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