Why the study?
Does chronic methylprednisolone infusion alter gene expression profiles in skeletal muscle compared to acute dosing in male adrenalectomized Wistar rats?
Does chronic methylprednisolone infusion alter gene expression profiles in skeletal muscle compared to acute dosing in male adrenalectomized Wistar rats?
Chronic methylprednisolone exposure results in gene expression profiles that do not entirely exhibit steroid tolerance, challenging current perspectives on glucocorticoid action mechanisms.
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Questions steroid tolerance assumptions with chronic dosing; leaves open human translation in skeletal muscle.
Almon et al. (2007) studied this question.
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