July 1, 1992Journal of Hypertension

Myocardial fibrosis and the concepts of cardioprotection and cardioreparation

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Why the study?

Does pharmacological interference with the renin-angiotensin-aldosterone system prevent or regress myocardial fibrosis in experimental models?

Population

Experimental models of myocardial fibrosis

Design

Review

Authors

KWKarl T. WeberHeart Failure / Cardiomyopathy CBChristian G. BrillaUniversitätsklinikum Tübingen SCScott E. CampbellFacility for Rare Isotope Beams

Discussion

Member takes

Implication

Supports RAAS blockade in experimental fibrosis; leaves open clinical translation and outcomes.

Structured PICO

Does pharmacological interference with the renin-angiotensin-aldosterone system prevent or regress myocardial fibrosis in experimental models?

Population

Experimental models of myocardial fibrosis (unilateral renal ischaemia, primary or secondary hyperaldosteronism)

Intervention

Pharmacological interference with the renin-angiotensin-aldosterone system (captopril, lisinopril, spironolactone, amiloride)

Outcome

Prevention or regression of myocardial fibrosis (reactive fibrosis and scarring)surrogate

Pharmacological blockade of the renin-angiotensin-aldosterone system prevents and regresses myocardial fibrosis in experimental models, providing a mechanistic basis for cardioprotection.

Cite This Study

Weber et al. (1992) studied this question.

synapsesocial.com/papers/6a780310d2fa2470761f405e https://doi.org/10.1097/00004872-199207001-00012

View Full Paper

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Myocardial fibrosis and the concepts of cardioprotection and cardioreparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myocardial fibrosis and the concepts of cardioprotection and cardioreparation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider