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December 1, 1993Journal of Biological ChemistryOpen Access

Regulatory elements that mediate expression of the gene for the angiotensin II type 1a receptor for the rat.

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Population

Rat vascular smooth muscle cells (A10), glial cells, and PC12 cells

Design

Preclinical

Authors

SMSatoshi MurasawaTufts UniversityHMHiroaki MatsubaraUniversity of Notre DameMUMasaya UrakamiKansai Medical University

Discussion

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Implication

Warrants no change in clinical practice; leaves open whether these rat elements regulate human AT1a-R expression in cardiovascular disease.

Structured PICO

P
Population
Rat vascular smooth muscle cells (A10), glial cells, and PC12 cells
I
Intervention
Transfection with various 5'-deletion mutants of the AT1a-R gene upstream region fused to the chloramphenicol acetyltransferase (CAT) gene
O
Outcome
Transcriptional activity (promoter activity)surrogate

Identifies multiple positive and negative cis-acting regulatory elements that mediate cell type-specific expression of the rat AT1a-R gene.

Cite This Study

Murasawa et al. (1993) studied this question.

synapsesocial.com/papers/6a780476576efb0ddaf7d2b9https://doi.org/10.1016/s0021-9258(19)74209-4
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1COUNTERPOINT: Molecular Analysis of the Angiotensin II Receptor*1992 · 40 citations
  2. 2Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.1991 · 245 citations
  3. 3Biochemical Properties of the Ovarian Granulosa Cell Type 2-Angiotensin II Receptor*1991 · 217 citations
  4. 4Changes of atrial natriuretic peptide and its messenger RNA with development and regression of cardiac hypertrophy in renovascular hypertensive rats.1990 · 43 citations
  5. 5Cell-Specific Expression of the Rat Insulin Gene: Evidence for Role of Two Distinct 5′ Flanking Elements1985 · 703 citations