Typhoid Fever; Estimation of Serum Lipid Levels and C-Reactive Protein

Objectives: The study was planned to see the serum lipid levels and c-reactiveproteins in patients with enteric (Typhoid) fever. Design: Comparative. Setting: Study wasconducted at the department of Pharmacology, University of veterinary and animal sciences,and Lahore. Period: from April 2014 to October 2014. Methodology: A total 100 subjectswere included in the study. Amongst them there were 50 patients with typhoid fever and 50normal individuals. All subjects fulfilled the criteria of inclusion in study and informed consentin written form was taken. Three millimetre venous blood was drawn from each subject, whowas centrifuged and serum was preserved for quantitative analysis of Total cholesterol (TC),Triglycerides (TGs), High-density lipoprotein-cholesterol (HDL-C), Low-density lipoproteincholesterol(LDL-C) and C-reactive protein (CRP). Results: According to this study there waselevation in the levels of TGs and decline was observed in the levels of HDL, LDL, and TC,which is due to lipid peroxidation in typhoid patients. This study highlighted the complexityof lipid variation during Salmonella typhi infection. Elevated level of C-reactive protein reflectsthe immune response to infection by typhoid patients. Conclusion: CRP may play a role inearly diagnosis of perforation in patients with typhoid fever. Typhoid fever causes biochemicalchanges and it should be further investigated to make them helpful for diagnosis.