Key result
Lactate serves as a metabolic biomarker in heart failure and may contribute to myocardial remodeling and inflammation, making lactate metabolism and lactylation potential therapeutic targets.
Why the study?
The mechanisms through which lactate impacts heart failure remain incompletely elucidated, and published findings are contradictory.
Design
Review
Authors
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May inform lactate monitoring in HF; leaves open whether modulating its signaling alters progression.
Lactate serves not only as a sensitive biomarker in heart failure but also plays a role in myocardial remodeling and inflammation, presenting a potential therapeutic target.
Zhang et al. (2026) conducted a review in Heart failure. Lactate was evaluated. Lactate serves as a metabolic biomarker in heart failure and may contribute to myocardial remodeling and inflammation, making lactate metabolism and lactylation potential therapeutic targets.
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