Population
Isolated porcine coronary arteries (vessel rings)
Design
Preclinical
Authors
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Should not change clinical practice; leaves open translation of cAMP-mediated coronary relaxation to human arteries.
Levosimendan produces endothelium-independent coronary vasorelaxation, with cAMP accumulation participating at high concentrations.
Gruhn et al. (1998) studied this question.
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