Why the study?
What are the pharmacokinetic properties of levosimendan in healthy volunteers and patients with mild congestive heart failure?
Population
16 participants (8 healthy volunteers and 8 patients with mild congestive heart failure)
Comparison
Single i.v. dose of 0.50 mg 14C-labeled… vs Healthy volunteers compared to patients with…
Authors
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Supports oral levosimendan dosing exploration in mild HF; leaves open efficacy confirmation in randomized trials.
What are the pharmacokinetic properties of levosimendan in healthy volunteers and patients with mild congestive heart failure?
Levosimendan demonstrates high oral bioavailability and similar pharmacokinetic profiles in both healthy volunteers and patients with mild congestive heart failure.
Sandell et al. (1995) studied this question.
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