Population
Rabbit isolated hearts with acute regional ischaemia induced by ligature of a branch of the circumflex…
Comparison
Levosimendan (cumulative concentrations, and 5 x… vs Milrinone (cumulative concentrations, and 10 M…
Design
Preclinical
Authors
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Does not support clinical adoption of levosimendan; leaves open translation of its potency and anti-ischemic effects from isolated hearts.
In an isolated rabbit heart model, levosimendan and milrinone demonstrated similar anti-ischaemic effects driven by improved myocardial perfusion, despite levosimendan having lower maximal inotropic and chronotropic efficacy.
Rump et al. (1994) studied this question.
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