September 1, 1988AJP Heart and Circulatory Physiology
Supersensitivity to acetylcholine of canine sinus and AV nodes after parasympathetic denervation
Population
Dogs (n=21)
Comparison
Parasympathetic denervation of the sinus and… vs Sham operation followed by acetylcholine infusion
Design
Preclinical
Follow-up
4 to 9 days
Authors
Discussion
Loading...
Member takes
Implication
Suggests denervation supersensitivity in canine nodes; leaves open translation to human post-vagal states.
Structured PICO
P
Population
Dogs (n=21)
I
Intervention
Parasympathetic denervation of the sinus (SAN) and atrioventricular (AVN) nodes by surgically removing parasympathetic ganglia and painting the area with phenol, followed by acetylcholine (ACh) infusion 4 to 9 days later
C
Comparator
Sham operation (thoracotomy without denervation) followed by acetylcholine (ACh) infusion
O
Outcome
ACh concentration required to prolong sinus cycle length (SCL) by 50%, 100%, and 300%, and to produce second degree and complete AV blocksurrogate
Vagally denervated sinus and AV nodes in dogs develop a supersensitive electrophysiological response to acetylcholine.
Cite This Study
Kaseda et al. (1988) studied this question.