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August 9, 2026Journal of Gynecologic OncologyOpen Access

Rising burden and deepening inequalities: a national study of high BMI-related uterine cancer in the United States using GBD and NHANES data

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Authors

JHJu HuangXWXinhui WuDXDingwen Xu

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Overview

National study demonstrates rising uterine cancer mortality linked to high BMI, indicating urgent need for interventions.

Key Points

  • This research aims to characterize the rising burden and inequalities of high BMI-related uterine cancer mortality in the U.S.
  • Utilized data from Global Burden of Disease 2023 and NHANES (1999-2023) for analysis.
  • Assessed trends in uterine cancer mortality and disability-adjusted life years using Joinpoint regression and AutoRegressive Integrated Moving Average.
  • Evaluated individual-level BMI associations with multivariable logistic regression.
  • U.S. ASMR and ASDR for high BMI-related uterine cancer significantly exceeded global averages, showing an increasing gap.
  • The most rapid increase in mortality occurred between 2009-2017, particularly in West Virginia and Mississippi.
  • Stronger associations between BMI and uterine cancer risk were found in obese individuals and non-Hispanic whites aged ≥50 years.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a782cfa2e1896536c83fba3https://doi.org/10.3802/jgo.2027.38.e12
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