What question did this study set out to answer?

This study aims to assess how maternal high-fat diet influences glial cell activity in the retinas of offspring, focusing on sex and estrous cycle dependency.

August 9, 2026Investigative Ophthalmology & Visual ScienceOpen Access

Maternal High-Fat Diet Induces Sex- and Estrous Cycle–Specific Glial Dysregulation in the Peripheral Offspring Retina

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GUGintare UrbonaiteVilnius University PCPatricija CepauskyteVilnius University NBNeda I. BiliuteVilnius University

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Randomized trial demonstrates retinal microglial dysregulation in offspring due to maternal high-fat diet, suggesting hormonal influence.

Key Points

This study aims to assess how maternal high-fat diet influences glial cell activity in the retinas of offspring, focusing on sex and estrous cycle dependency.
Female C57Bl/6J mice were fed control (10% fat) or high-fat diet (60% fat) from weaning to lactation.
After weaning to a normal rodent diet, retinal structure and glial cells were analyzed using immunohistochemical labeling.
Correlations were made between observed retinal changes in female offspring and the stages of the estrous cycle.
mHFD caused subtle retinal structural changes and sex-specific variations in glial cells.
Male offspring had a reduced microglial area and increased lysosomal profile, while females displayed the opposite.
Under control diet, microglial area fluctuated with estrous cycle, but mHFD diminished these differences.

Cite This Study

Urbonaite et al. (2026) studied this question.

synapsesocial.com/papers/6a782d182e1896536c83fdd9 https://doi.org/10.1167/iovs.67.10.20

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Maternal High-Fat Diet Induces Sex- and Estrous Cycle–Specific Glial Dysregulation in the Peripheral Offspring Retina

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Cite This Study

Maternal High-Fat Diet Induces Sex- and Estrous Cycle–Specific Glial Dysregulation in the Peripheral Offspring Retina

Discussion

Member takes

Implication

Key Points

Cite This Study

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