Research Progress in Fluorinated Isoquinoline-1,3-diones

Fluorinated isoquinoline-1,3-diones possess important biological activities and application value in many fields such as medicine, pesticides, and organic synthesis. This review summarizes the synthetic methods of fluorinated isoquinoline-1,3-diones reported in recent years, mainly including classical synthetic methods, visible-light-induced catalytic methods, and electroorganic synthesis. The mechanisms of each reaction are described. Among them, visible-light-induced and electrochemical approaches show improved sustainability and mild reaction conditions. In this review, these synthetic methods are summarized to provide a reference for the design and research of these compounds. Future perspectives on method development are also briefly considered.