Key result
Higher C-reactive protein-triglyceride glucose index linked to ~19% increased incident CHD risk in hypertension.
Why the study?
Does an elevated C-reactive protein-triglyceride glucose index (CTI) predict incident cardiovascular disease in individuals with hypertension?
Cohort (n=168,186)
Yes
Does an elevated C-reactive protein-triglyceride glucose index (CTI) predict incident cardiovascular disease in individuals with hypertension?
Hazard Ratio: 1.19 (95% CI 1.15–1.23)
Elevated C-reactive protein-triglyceride glucose index (CTI) is robustly associated with increased risks of CHD, AF, HF, and stroke in individuals with hypertension, suggesting its potential as a predictive biomarker.
Background: The C-reactive protein-triglyceride glucose index (CTI) has recently been introduced as a novel composite biomarker that integrates inflammation and insulin resistance. However, the association between CTI and incident cardiovascular disease (CVD) in individuals with hypertension remains unclear. Methods: We included 168,186 participants from the UK Biobank in this longitudinal analysis. The primary outcomes were incident coronary heart disease (CHD), atrial fibrillation (AF), heart failure (HF), and stroke. Cox proportional hazards regression was performed to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations between CTI and incident CVD outcomes. Results: In this study, CTI showed significant positive linear associations with CHD (HR, 1.19; 95% CI, 1.15 to 1.23) and stroke (HR, 1.14; 95% CI, 1.07 to 1.21), whereas nonlinear associations were observed for AF (HR, 1.08; 95% CI, 1.04 to 1.13) and HF (HR, 1.36; 95% CI, 1.28 to 1.44) among participants with hypertension. Furthermore, subgroup and sensitivity analyses confirmed the robustness of these associations. Conclusion: Our findings showed that elevated CTI levels were robustly associated with increased risks of CHD, AF, HF, and stroke, suggesting that CTI may serve as a promising predictive marker for CVD in individuals with hypertension.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2026) conducted a cohort in Hypertension (n=168,186). C-reactive protein-triglyceride glucose index (CTI) was evaluated on Incident coronary heart disease (CHD) (HR 1.19, 95% CI 1.15-1.23). Elevated C-reactive protein-triglyceride glucose index was associated with increased risks of incident CHD (HR 1.19; 95% CI 1.15-1.23), stroke, AF, and HF in individuals with hypertension.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: