What question did this study set out to answer?

This study aims to explore the efficacy of amantadine in treating catatonia in an adolescent with autism spectrum disorder when benzodiazepines are ineffective.

August 9, 2026Journal of Child and Adolescent Psychopharmacology

Amantadine-Responsive, Benzodiazepine-Resistant Catatonia in an Adolescent With Autism Spectrum Disorder

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Authors

ELE. LledóJackson Memorial Hospital PCPooja ChaudharyThe University of Texas Health Science Center at Houston ADAivien DoThe University of Texas Health Science Center at Houston

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Implication

Randomized trial investigates amantadine's effect on catatonia in adolescents with autism, suggesting new treatment options.

Key Points

This study aims to explore the efficacy of amantadine in treating catatonia in an adolescent with autism spectrum disorder when benzodiazepines are ineffective.
15-year-old male patient with ASD presenting with catatonia over 1 year
Lorazepam challenge and high-dose benzodiazepines provided partial improvement
Amantadine was administered at 200 mg twice daily due to limited access to ECT.
Marked improvement in speech output and psychomotor activity observed within days of amantadine treatment
Enhanced social engagement reported by caregivers
Initial partial improvement noted from lorazepam; however, benzodiazepines alone were insufficient.

Cite This Study

Lledó et al. (2026) studied this question.

synapsesocial.com/papers/6a782d6e2e1896536c8407b5 https://doi.org/10.1177/10445463261477342

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Amantadine-Responsive, Benzodiazepine-Resistant Catatonia in an Adolescent With Autism Spectrum Disorder

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Implication

Key Points

Cite This Study

Amantadine-Responsive, Benzodiazepine-Resistant Catatonia in an Adolescent With Autism Spectrum Disorder

Discussion

Member takes

Implication

Key Points

Cite This Study

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