What question did this study set out to answer?

To evaluate the relationship between NIHSS score changes and laboratory parameters in acute ischemic stroke patients treated with IV thrombolysis.

August 9, 2026BMC Neurology0 citationsOpen Access

Assessment Of Thrombolytic Therapy Response In Acute Ischemic Stroke Using NIHSS Changes

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Acute ischemic stroke (n=33). Intervention: Baseline serum calcium and basophil levels vs. Patients without clinical improvement. Primary outcome: Clinical improvement (≥4-point reduction in NIHSS score at 24 hours) (AUC 0.813, 95% CI 0.645-0.981, p=0.005).

Assessment of intravenous thrombolytic therapy response in acute ischemic stroke using NIHSS changes and laboratory parameters

Why the study?

Do baseline laboratory parameters (calcium and basophils) predict clinical response to intravenous thrombolytic therapy in patients with acute ischemic stroke?

Population

33 adult patients with a confirmed diagnosis of acute ischemic stroke who presented to the emergency…

Design

Cohort

Follow-up

3 months

Key result

Higher baseline basophil levels demonstrated significant discriminative ability in predicting early clinical improvement (AUC 0.813) in acute ischemic stroke patients receiving intravenous thrombolytic therapy.

Authors

SNSüleyman Nogay TDTurgut Dolanbay BDBilgehan Demir

Discussion

Member takes

Overview

May improve prognostic accuracy by pairing NIHSS with labs after IVTT; leaves open validation in prospective cohorts.

Key Points

To evaluate the relationship between NIHSS score changes and laboratory parameters in acute ischemic stroke patients treated with IV thrombolysis.
Retrospective analysis of 33 acute ischemic stroke patients treated with IVTT in 2024.
Baseline and 24-hour NIHSS scores were recorded, along with hemogram and biochemical analyses.
Associations of clinical response with mortality and hemorrhagic complications were statistically evaluated.
Three-month mortality was 15.2%, and the hemorrhage rate was 9.1%.
Platelet levels were significantly lower in patients who died, and NIHSS scores at 24 hours were associated with mortality and hemorrhage.
Serum calcium and basophil levels correlated with clinical improvement, with basophil showing a higher discriminative ability in ROC analysis.

Study Design

Type

Observational (n=33)

Multicenter

Structured PICO

Do baseline laboratory parameters (calcium and basophils) predict clinical response to intravenous thrombolytic therapy in patients with acute ischemic stroke?

Population

33 adult patients with acute ischemic stroke who received intravenous thrombolytic therapy, evaluated for early clinical response at 24 hours and followed for 3-month mortality.

Exposure

Intravenous thrombolytic therapy (IVTT) with recombinant tissue plasminogen activator (rt-PA)

Outcome

Clinical response defined as a ≥4-point reduction in NIHSS score at 24 hours after IVTTsurrogate

Higher baseline basophil and serum calcium levels may predict early clinical improvement following intravenous thrombolytic therapy in patients with acute ischemic stroke, though larger studies are needed to confirm these exploratory findings.

Main Result

Effect estimate: AUC 0.813 (95% CI 0.645-0.981)

p-value: p=0.005

Limitations

Retrospective design relying on patient records
Small sample size (n=33) and limited number of hemorrhagic cases
Lack of multivariable analysis to control for confounding variables
Exclusion of patients receiving antiplatelet or anticoagulant therapy limits generalizability
Risk of overfitting and unstable estimates in ROC analyses due to small sample size
Small sample size
Exploratory nature of the analysis
Univariable analyses without controlling for potential confounding factors
Retrospective design

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Cite This Study

Nogay et al. (2026) conducted an observational in Acute ischemic stroke (n=33). Baseline serum calcium and basophil levels vs. Patients without clinical improvement was evaluated on Clinical improvement (≥4-point reduction in NIHSS score at 24 hours) (AUC 0.813, 95% CI 0.645-0.981, p=0.005). Higher baseline basophil levels demonstrated significant discriminative ability in predicting early clinical improvement (AUC 0.813) in acute ischemic stroke patients receiving intravenous thrombolytic therapy.

synapsesocial.com/papers/6a782d7b2e1896536c840a63 https://doi.org/10.1186/s12883-026-05228-2

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August 9, 2026BMC Neurology0 citationsOpen Access

Assessment Of Thrombolytic Therapy Response In Acute Ischemic Stroke Using NIHSS Changes

Assessment of intravenous thrombolytic therapy response in acute ischemic stroke using NIHSS changes and laboratory parameters

Why the study?

Do baseline laboratory parameters (calcium and basophils) predict clinical response to intravenous thrombolytic therapy in patients with acute ischemic stroke?

Population

33 adult patients with a confirmed diagnosis of acute ischemic stroke who presented to the emergency…

Design

Cohort

Follow-up

3 months

Key result

Authors

SNSüleyman Nogay TDTurgut Dolanbay BDBilgehan Demir

Discussion

Member takes

Overview

May improve prognostic accuracy by pairing NIHSS with labs after IVTT; leaves open validation in prospective cohorts.

Key Points

To evaluate the relationship between NIHSS score changes and laboratory parameters in acute ischemic stroke patients treated with IV thrombolysis.
Retrospective analysis of 33 acute ischemic stroke patients treated with IVTT in 2024.
Baseline and 24-hour NIHSS scores were recorded, along with hemogram and biochemical analyses.
Associations of clinical response with mortality and hemorrhagic complications were statistically evaluated.
Three-month mortality was 15.2%, and the hemorrhage rate was 9.1%.
Platelet levels were significantly lower in patients who died, and NIHSS scores at 24 hours were associated with mortality and hemorrhage.
Serum calcium and basophil levels correlated with clinical improvement, with basophil showing a higher discriminative ability in ROC analysis.

Study Design

Type

Observational (n=33)

Multicenter

Structured PICO

Do baseline laboratory parameters (calcium and basophils) predict clinical response to intravenous thrombolytic therapy in patients with acute ischemic stroke?

Population

33 adult patients with acute ischemic stroke who received intravenous thrombolytic therapy, evaluated for early clinical response at 24 hours and followed for 3-month mortality.

Exposure

Intravenous thrombolytic therapy (IVTT) with recombinant tissue plasminogen activator (rt-PA)

Outcome

Clinical response defined as a ≥4-point reduction in NIHSS score at 24 hours after IVTTsurrogate

Main Result

Effect estimate: AUC 0.813 (95% CI 0.645-0.981)

p-value: p=0.005

Limitations

Retrospective design relying on patient records
Small sample size (n=33) and limited number of hemorrhagic cases
Lack of multivariable analysis to control for confounding variables
Exclusion of patients receiving antiplatelet or anticoagulant therapy limits generalizability
Risk of overfitting and unstable estimates in ROC analyses due to small sample size
Small sample size
Exploratory nature of the analysis
Univariable analyses without controlling for potential confounding factors
Retrospective design

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Cite This Study

synapsesocial.com/papers/6a782d7b2e1896536c840a63 https://doi.org/10.1186/s12883-026-05228-2

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