Key result
Exercise-induced ventricular arrhythmias linked to ~180% higher risk of adverse arrhythmic events in arrhythmogenic cardiomyopathy.
Why the study?
Exercise has the potential to unmask ventricular arrhythmias in arrhythmogenic cardiomyopathy, but the prevalence and prognostic significance of exercise-induced ventricular arrhythmias during exercise tests required assessment.
Does the presence of exercise-induced ventricular arrhythmias predict adverse arrhythmic outcomes in patients with arrhythmogenic cardiomyopathy?
Cohort (n=157)
No
Does the presence of exercise-induced ventricular arrhythmias predict adverse arrhythmic outcomes in patients with arrhythmogenic cardiomyopathy?
Hazard Ratio: 2.8 (95% CI 1.1–7.3)
p-value: p=0.03
Exercise-induced ventricular arrhythmias occur in nearly 40% of ACM patients and are independently associated with adverse arrhythmic outcomes, supporting the integration of exercise testing into routine risk stratification.
No takes yet. Share an insight, caveat, or question.
EIVAs may identify higher-risk ACM patients; leaves open whether exercise testing refines risk stratification.
Mengozzi et al. (2026) conducted a cohort in arrhythmogenic cardiomyopathy (n=157). Exercise-induced ventricular arrhythmias vs. Absence of exercise-induced ventricular arrhythmias was evaluated on Composite of sustained ventricular tachycardia/fibrillation, appropriate implantable cardioverter-defibrillator therapy, sudden cardiac arrest and sudden death (HR 2.8, 95% CI 1.1 to 7.3, p=0.03). Exercise-induced ventricular arrhythmias were independently associated with an increased risk of adverse arrhythmic outcomes (HR 2.8; 95% CI 1.1-7.3; p=0.03) in arrhythmogenic cardiomyopathy.
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