Arrhythmogenic response to isoproterenol testing vs. exercise testing in arrhythmogenic right ventricular cardiomyopathy patients
Key result
Isoproterenol testing induced a significantly higher incidence of polymorphic ventricular arrhythmias compared to exercise testing in newly diagnosed ARVC patients (89.2% vs. 43.2%, P<0.0001).
Why the study?
Does isoproterenol testing improve the detection of polymorphic ventricular arrhythmias compared to exercise testing in newly diagnosed ARVC patients?
Population
37 newly diagnosed arrhythmogenic right ventricular cardiomyopathy patients and a control group referred for…
Comparison
Isoproterenol testing vs Exercise testing
Design
Cohort
Authors
Discussion
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Implication
Isoproterenol testing may unmask more arrhythmias than exercise in early ARVC; leaves open its added value for risk stratification.
Study Design
Type
Cross-Sectional (n=37)
Structured PICO
Does isoproterenol testing improve the detection of polymorphic ventricular arrhythmias compared to exercise testing in newly diagnosed ARVC patients?
P
Population
37 newly diagnosed ARVC patients (mean age 38, 36.5% female) and a control group underwent isoproterenol and exercise testing to evaluate arrhythmic response.
E
Exposure
Isoproterenol testing (continuous infusion 45 µg/min for 3 min)
C
Comparator
Exercise testing (workload increased by 30 W every 3 min)
O
Outcome
Incidence of (i) polymorphic premature ventricular contractions (PVCs) and couplet(s) or (ii) sustained or non-sustained ventricular tachycardia (VT) with left bundle branch block (excluding right ventricular outflow tract VT)surrogate
Main Result
Absolute Event Rate: 89.2% vs 43.2%
p-value: p=< 0.0001
Isoproterenol testing is significantly more arrhythmogenic than exercise testing in newly diagnosed ARVC patients, suggesting it may have superior diagnostic utility for detecting characteristic ventricular arrhythmias.
Cite This Study
Denis et al. (2018) conducted a cross-sectional in Arrhythmogenic right ventricular cardiomyopathy (ARVC) (n=37). Isoproterenol testing vs. Exercise testing was evaluated on Incidence of polymorphic ventricular arrhythmias (p=< 0.0001). Isoproterenol testing induced a significantly higher incidence of polymorphic ventricular arrhythmias compared to exercise testing in newly diagnosed ARVC patients (89.2% vs. 43.2%, P<0.0001).