Key result
Transcatheter septal closure is linked to ~62% less perioperative heart failure than open surgery.
Why the study?
The risk of developing acute and subacute heart failure perioperatively after septal heart defect closure remains underestimated, particularly in young children with pre-existing haemodynamic compromise.
Does the combination of NT-proBNP and ST2 predict early postoperative heart failure in children undergoing correction of septal defects?
Cohort (n=82)
No
Does the combination of NT-proBNP and ST2 predict early postoperative heart failure in children undergoing correction of septal defects?
Absolute Event Rate: 11.5% vs 30%
p-value: p=0.031
The combined assessment of NT-proBNP and ST2 provides high prognostic accuracy for predicting early postoperative heart failure in children undergoing correction of septal defects.
Alerts to underestimated perioperative HF risk in young children; leaves open need for validated risk stratification.
Transcatheter closure of septal heart defects in children has long ceased to be an experimental technique – today it is a routine alternative to open surgery. However, the risk of developing acute and subacute heart failure in the perioperative period remains underestimated, particularly in young children with pre-existing haemodynamic compromise. This study presents the results of a prospective cohort study involving 82 children with septal heart defects, divided into an interventional closure group (n = 52) and an open-heart surgery group with cardiopulmonary bypass (n = 30). The dynamics of NT-proBNP, galectin-3, soluble ST2 and high-sensitivity troponin I were studied in the pre-operative period and over the 7 days following the procedure. It was found that the combination of NT-proBNP and ST2 had the greatest prognostic value with regard to the development of early postoperative heart failure (AUC 0.86; p<0.001). The data obtained support the recommendation that these biomarkers be included in the standard protocol for perioperative monitoring of children undergoing endovascular repair of septal defects.
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О. et al. (2026) conducted a cohort in Septal heart defects (n=82). Transcatheter closure of septal defects vs. Open-heart surgery with cardiopulmonary bypass was evaluated on Development of perioperative heart failure (p=0.031). Transcatheter closure of septal defects had lower perioperative heart failure rates than open surgery (11.5% vs 30.0%), and the NT-proBNP/ST2 combination strongly predicted this risk (AUC 0.86).
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