Validation of SeptiCyte RAPID to Discriminate Sepsis From Noninfectious Systemic Inflammation in Critically Ill Children

Jerry J. Zimmerman; Sainath Raman; Warwick Butt; Silvia Cermelli; Roy F. Davis; Elizabeth Y. Killien; Shane George; Kristen S. Gibbons; Adam D. Irwin; Krupa A. Navalkar; Thomas D. Yager; Florian H. Zapf; Lachlan Coin; Luregn J. Schlapbach; Richard B. Brandon

doi:10.1097/pcc.0000000000004027

August 7, 2026Pediatric Critical Care Medicine

Validation of SeptiCyte RAPID to Discriminate Sepsis From Noninfectious Systemic Inflammation in Critically Ill Children

View Full Paper

Ask AI

Bookmark

Share

Key Points

The aim is to validate SeptiCyte RAPID as a biomarker for distinguishing sepsis from noninfectious systemic inflammation in critically ill children.
Retrospective clinical validation study with n=284 critically ill children aged 1 month to 18 years.
Assessment of SeptiCyte RAPID performance using area under the curve (AUC) and likelihood ratios compared with retrospective physician diagnosis.
Integration of clinical parameters to enhance diagnostic accuracy via binomial logistic regression.
SeptiCyte RAPID AUC for sepsis identification ranged from 0.80 to 0.83.
Integration of clinical parameters increased the AUC to 0.86 (95% CI, 0.85-0.87).
Findings suggest SeptiCyte RAPID performs similarly in children as in adults.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Implication

Retrospective validation study demonstrates SeptiCyte RAPID’s diagnostic capability for sepsis in critically ill children, highlighting its potential utility.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Zimmerman et al. (2026) studied this question.

synapsesocial.com/papers/6a782d962e1896536c840d6a https://doi.org/10.1097/pcc.0000000000004027

View Full Paper

Ask AI

Bookmark

Share

Validation of SeptiCyte RAPID to Discriminate Sepsis From Noninfectious Systemic Inflammation in Critically Ill Children

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Validation of SeptiCyte RAPID to Discriminate Sepsis From Noninfectious Systemic Inflammation in Critically Ill Children

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Keep reading

Keep reading