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August 9, 2026Viral Immunology

Comparative Analysis of Nucleocapsid- and Spike-Specific Isotype Humoral Immune Responses Following Natural SARS-CoV-2 Infection and Vaccination with Sinopharm, Sinovac, and AstraZeneca

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Authors

MNMohamed H. NasraaNational Research CentreDADina Nadeem Abd‐ElshafyNational Research CentreRNRola NadeemNational Research Centre

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Implication

Randomized trial compares humoral immune responses in infected individuals and vaccine recipients, suggesting diagnostic utility of nucleocapsid.

Key Points

  • The study aims to compare nucleocapsid and spike-specific antibody responses in those infected with SARS-CoV-2 and in recipients of various vaccinations.
  • Comparison of antibody responses using ELISA kits
  • Population includes infected humans from April–August 2020 and vaccinated individuals
  • Assessment of IgG and IgM positivity rates for nucleocapsid and spike antigens.
  • Infection resulted in 80.9% IgG positivity for nucleocapsid vs. 42.8% for spike (p < 0.05)
  • Vaccinated cohorts showed 83-100% IgG positivity against both antigens, with low IgM levels (p < 0.05)
  • Natural infection showed significant correlation in antibody responses between nucleocapsid and spike antigens.

Cite This Study

Nasraa et al. (2026) studied this question.

synapsesocial.com/papers/6a782d962e1896536c840d9dhttps://doi.org/10.1177/08828245261474281
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