Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 5, 2023Open Access

Left Ventricular Remodeling Response to SGLT2 inhibitors in Heart Failure: An Updated Meta-analysis of Randomized Controlled Studies

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Randomized controlled trials have reported contrasting results regarding reverse left ventricular remodeling after SGLT2i therapy in patients with heart failure.

Do SGLT2 inhibitors improve left ventricular remodeling in outpatients with heart failure?

Population

1385 HF outpatients across 9 RCTs

Comparison

SGLT2i administration vs control

Design

Meta-analysis of RCTs

Authors

ECErberto CarluccioPBPaolo BiagioliGRGianpaolo Reboldi

Discussion

Loading...

Member takes

Overview

SGLT2i promote reverse LV remodeling in HFrEF outpatients; reinforces and extends evidence from prior heterogeneous RCTs.

Structured PICO

Do SGLT2 inhibitors improve left ventricular remodeling in outpatients with heart failure?

P
Population
9 RCTs pooling 1385 outpatients with heart failure
I
Intervention
SGLT2 inhibitors
O
Outcome
Change in absolute LV end-diastolic (LVEDV) and end-systolic volume (LVESV) from baseline to study endpointsurrogate

SGLT2 inhibitors significantly reverse cardiac remodeling and improve left ventricular systolic function and mass in heart failure patients, particularly those with HFrEF.

Cite This Study

Carluccio et al. (2023) studied this question.

synapsesocial.com/papers/6a783adcd2fa2470761f5cd7https://doi.org/10.21203/rs.3.rs-2868404/v1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left ventricular remodeling response to SGLT2 inhibitors in heart failure: an updated meta-analysis of randomized controlled studies2023 · 76 citations
  2. 2Imaging-based Demonstration of Reverse Left Heart Remodeling after Sodium–Glucose Co-transporter 2 Inhibitors in Heart Failure: A Systematic Review and Meta-analysis2026
  3. 3Impact of SGLT2 Inhibition on Markers of Reverse Cardiac Remodelling in Heart Failure: Systematic Review and Meta-Analysis2024 · 27 citations
  4. 4Effect of sodium-glucose cotransporter-2 inhibitors on cardiac remodelling: a systematic review and meta-analysis2021 · 80 citations
  5. 5Imaging and Hemodynamic Mechanisms of Cardiac Remodeling with SGLT2 Inhibitors Across Heart Failure Phenotypes: A Systematic Review2026