Key result
An elevated triglyceride-glucose index is significantly associated with an increased risk of major adverse cardiovascular events (HR 1.66) in patients with coronary artery disease.
Why the study?
The triglyceride-glucose index correlates with cardiovascular risk, but its association with major adverse cardiovascular events in coronary artery disease required systematic evaluation.
Does an elevated triglyceride-glucose (TyG) index increase the risk of major adverse cardiovascular events in patients with coronary artery disease?
Meta-Analysis (n=50,793)
Does an elevated triglyceride-glucose (TyG) index increase the risk of major adverse cardiovascular events in patients with coronary artery disease?
Answers are grounded in this paper and cite their sources.
An elevated triglyceride-glucose (TyG) index is significantly associated with an increased risk of MACEs and other adverse cardiovascular outcomes in patients with coronary artery disease, suggesting its utility as a simple biomarker for risk stratification.
BACKGROUND: The triglyceride-glucose (TyG) index has been shown to correlate with cardiovascular risk. This meta-analysis aims to evaluate the incidence of the TyG index on the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary artery disease (CAD). METHODS: A systematic literature search was conducted in the Web of Science, PubMed, and Embase databases from their inception until December 18, 2024. Studies that examined the association between the TyG index and the risk of MACEs in patients with CAD were included. Adjusted hazard ratios (HRs) with 95% confidence intervals (CIs) were aggregated using a random-effects model. Statistical analysis was performed using STATA 14.0. RESULTS: A total of 23 studies encompassing 50,793 subjects were ultimately incorporated into this meta-analysis. The findings indicated that an elevated TyG index correlates with an increased risk of MACEs (HR = 1.66, 95% CI [1.47-1.88], P < .0001), all-cause mortality (HR = 1.36, 95% CI [1.12-1.66], P = .002), cardiovascular mortality (HR = 1.44, 95% CI [1.00-2.06], P = .049), myocardial infarction (HR = 1.72, 95% CI [1.33-2.23], P < .0001), stroke (HR = 1.60, 95% CI [1.23-2.07], P < .0001), and revascularization procedures (HR = 1.82, 95% CI [1.41-2.36], P < .0001) among CAD patients. CONCLUSION: This meta-analysis underscores the association between the TyG index and an elevated risk of MACEs in CAD patients.
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Lai et al. (2025) conducted a meta-analysis in Coronary artery disease (n=50,793). Elevated triglyceride-glucose (TyG) index vs. Lower triglyceride-glucose (TyG) index was evaluated on Major adverse cardiovascular events (MACEs) (HR 1.66, 95% CI 1.47-1.88, p=<0.0001). An elevated triglyceride-glucose index is significantly associated with an increased risk of major adverse cardiovascular events (HR 1.66) in patients with coronary artery disease.
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