Why the study?
Although the triglyceride-glucose index is associated with cardiometabolic diseases like hypertension, its prognostic role for major adverse cardiovascular events in hypertensive patients was unknown.
Does a higher TyG index predict major adverse cardiovascular events in hypertensive patients?
Does a higher TyG index predict major adverse cardiovascular events in hypertensive patients?
The TyG index is a reliable prognostic marker for predicting MACE and mortality in hypertensive patients, regardless of age, gender, or diabetic status.
May aid MACE risk stratification in hypertension; extends meta-analytic evidence for TyG as prognostic marker.
Triglyceride- glucose (TyG) index, a marker of insulin resistance, has been shown to be associated with the incidence of cardiometabolic diseases including hypertension. However, the prognostic role of TyG index is unknown. Hence, we aim to determine the association of TyG index with major adverse cardiovascular events (MACE) in hypertensive patients. Systematic searching was conducted on 3 databases up till November 2024. We included studies with hypertensive patients despite their comorbidities. Outcome measured is MACE and its individual components. Random effect model meta-analysis is done to pool the results with similar reference point. Twenty observational studies with a total of 451,455 patients of 40 – 70 years old are included. Meta-analysis result shows that higher TyG index is associated with a statistically significant increased risk of MACE (HR 1.90, CI: 1.41 – 2.57, I 2 88 %), myocardial infarction (HR 1.55, CI: 1.27 – 1.88, I 2 0 %), stroke (HR 1.84, CI: 1.41 – 2.39, I 2 62 %), all- cause mortality (HR 1.86, CI: 1.70 – 2.03, I 2 0 %) and cardiovascular mortality (HR 1.08, CI: 1.04 – 1.11, I 2 0 %). Subgroups of older and younger population, male and female gender, diabetic and non- diabetic population, and higher BMI patients retains the statistically significant risk of MACE ( p < 0.05). U- shaped phenomena of TyG index is also demonstrated with the risk of all- cause mortality. TyG index is a reliable prognostic marker of MACE in hypertensive patients and can be utilized in population despite their age, diabetic status, and gender. Summary findings of the association of TyG index with major adverse cardiovascular events
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Dakota et al. (2025) studied this question.
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