Key result
Prosthesis-patient mismatch worsens outcomes after SAVR, but its prognostic role in TAVR remains uncertain.
Why the study?
Although prosthesis-patient mismatch has demonstrated strong prognostic value following SAVR, its significance in TAVR remains uncertain.
Does prosthesis-patient mismatch impact clinical outcomes in patients undergoing surgical or transcatheter aortic valve replacement?
Does prosthesis-patient mismatch impact clinical outcomes in patients undergoing surgical or transcatheter aortic valve replacement?
While PPM is a robust predictor of adverse outcomes after SAVR, its prognostic significance after TAVR is inconsistent, prompting the exploration of alternative metrics like the fitting index.
Almost half a century ago, cardiac surgeons introduced the concept of prosthesis-patient mismatch (PPM), which was defined by indexing the effective orifice area (EOA) to body surface area. Although PPM has demonstrated strong prognostic value following surgical aortic valve replacement (SAVR), its significance in transcatheter aortic valve replacement (TAVR) remains uncertain. In this review, we revisit the concept of PPM and explore the methodological and clinical challenges in its application. Special focus is given to the limitations in interpreting EOA and indexed EOA (EOAi), including flow dependency and imaging variability. We also review the literature evaluating the association between PPM and clinical outcomes after SAVR and TAVR. Finally, we discuss a potential role of alternative metric such as the fitting index.
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Tobe et al. (2026) conducted a review in Aortic valve replacement (SAVR and TAVR). Prosthesis-patient mismatch vs. No prosthesis-patient mismatch was evaluated. Prosthesis-patient mismatch is consistently associated with worse clinical outcomes following surgical aortic valve replacement, but its prognostic significance in transcatheter aortic valve replacement remains uncertain.
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