April 16, 1981New England Journal of Medicine

Hemodialysis Using Prostacyclin Instead of Heparin as the Sole Antithrombotic Agent

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Why the study?

Does prostacyclin prevent clotting and hemorrhage in patients undergoing hemodialysis?

Population

n=11 patients

Design

Case_series

Follow-up

240 minutes

Authors

RZRandall M. ZusmanMassachusetts General Hospital RRRobert H. RubinBoston University ACAllen CatoUniversity of North Carolina at Chapel Hill

Discussion

Member takes

Implication

May support prostacyclin as sole antithrombotic in hemodialysis; hypothesis-generating case report requiring controlled trials.

Structured PICO

Does prostacyclin prevent clotting and hemorrhage in patients undergoing hemodialysis?

Population

n=11 patients (10 on long-term hemodialysis and 1 undergoing dialysis for acute renal failure who previously bled severely with heparin)

Intervention

Prostacyclin infused intravenously for 10 minutes before dialysis and into the arterial line of the dialyzer during dialysis (mean total dose 423 +/- 91 ng/kg)

Outcome

Prevention of clotting of the coil and occurrence of hemorrhages during 240 minutes of dialysissafety

Prostacyclin can safely be used as the sole antithrombotic agent during hemodialysis, offering an alternative to heparin, especially when systemic anticoagulation is contraindicated.

Cite This Study

Zusman et al. (1981) studied this question.

synapsesocial.com/papers/6a78511f7ecc675f86aeec2b https://doi.org/10.1056/nejm198104163041603

View Full Paper

Ask AI

Bookmark

Hemodialysis Using Prostacyclin Instead of Heparin as the Sole Antithrombotic Agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Hemodialysis Using Prostacyclin Instead of Heparin as the Sole Antithrombotic Agent

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider