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REGIONAL heparinization has been a useful adjunct to hemodialysis since its introduction several years ago.1 Experience with the procedure, as reported by several authors,2 , 3 has generally been satisfactory. In principle, regional heparinization involves the constant infusion of heparin into the arterial arm of the dialyzer and neutralization of the heparin by protamine on the venous side. If the heparin-to-protamine ratio is properly adjusted only neutralized heparin enters the patient, and theoretically this should not affect his coagulation parameters. This technic allows anticoagulation of the artificial kidney without anticoagulation of the patient and its attendant risks.Some time ago, we noted . . .
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Hampers et al. (1966) studied this question.
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