Key result
Small-vessel disease etiology in recurrent TIA was associated with a significantly higher 7-day stroke risk compared to non-SVD etiology (41.7% vs 5.5%; OR 12.3; 95% CI 3.7-41.9; P<0.0001).
Population
1,000 consecutive patients with incident and recurrent TIAs in a prospective, population-based study.
Design
Cohort
Follow-up
7 days
Authors
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May prompt intensified monitoring for recurrent TIA with SVD etiology; leaves open whether etiology-specific prevention alters outcomes.
Cohort (n=1,000)
Odds Ratio: 12.3 (95% CI 3.7–41.9)
Absolute Event Rate: 41.7% vs 5.5%
p-value: p=<0.0001
Capsular warning syndrome carries a 60% 7-day stroke risk, whereas other recurrent TIAs within 7 days do not confer a higher stroke risk than a single TIA.
Paul et al. (2012) conducted a cohort in Transient Ischemic Attack (TIA) (n=1,000). Small-vessel disease (SVD) etiology vs. Non-SVD etiology was evaluated on 7-day risk of stroke (OR 12.3, 95% CI 3.7-41.9, p=<0.0001). Small-vessel disease etiology in recurrent TIA was associated with a significantly higher 7-day stroke risk compared to non-SVD etiology (41.7% vs 5.5%; OR 12.3; 95% CI 3.7-41.9; P<0.0001).
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