Key result
The epicardium and epicardially-derived cells play a crucial role in the formation of the atrioventricular junction, annulus fibrosus, and parietal AV valve leaflets in the murine heart.
Population
Murine heart models for the study of the epicardial lineage
Design
Review
Authors
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May inform congenital AV defect models; leaves open human translation from murine epicardial findings.
This review highlights the critical role of epicardially-derived cells in the development of the atrioventricular junction, annulus fibrosus, and AV valve leaflets in murine models.
Lockhart et al. (2014) conducted a review in Cardiac development (murine heart). The epicardium and epicardially-derived cells play a crucial role in the formation of the atrioventricular junction, annulus fibrosus, and parietal AV valve leaflets in the murine heart.
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