Key result
Elevated myeloperoxidase serum levels were a significant predictor for a SYNTAX score >32 in patients with STEMI (OR 1.055; 95% CI 1.007-1.101; p=0.009).
Why the study?
Although myeloperoxidase is a recognized biomarker in various cardiovascular diseases, its relationship with the SYNTAX score in patients with STEMI after PCI required exploration.
Is elevated myeloperoxidase associated with a higher SYNTAX score in patients with STEMI after PCI?
Cross-Sectional (n=93)
Is elevated myeloperoxidase associated with a higher SYNTAX score in patients with STEMI after PCI?
Odds Ratio: 1.055 (95% CI 1.007–1.101)
p-value: p=0.009
Elevated myeloperoxidase levels are significantly associated with a higher SYNTAX score (>32) in patients with STEMI undergoing PCI.
MPO may identify complex lesions in STEMI; leaves open whether it adds value to existing risk scores.
Aims:There is evidence that myeloperoxidase (MPO) is a significant biomarker in various cardiovascular diseases. This work explored the relationship between MPO serum levels and SYNTAX (Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery trial) score in patients with ST Elevation Myocardial Infarction (STEMI) after percutaneous coronary intervention.Methods:The study design was observational and cross-sectional with prospective patient enrollment. Patients were divided into two groups: those with a SYNTAX score >32 and those with a SYNTAX score ≤32. The SYNTAX score was calculated based on the SYNTAX 2.2 score calculator (syntaxscore.org). Patients were analyzed for demographic, and clinical characteristics, including body mass index, carbohydrate and lipid metabolic balance, troponin, and MPO levels. The MPO was measured by ELISA.Results:Ninety-three patients with STEMI were enrolled with a mean age of 63.77±8.55 years, and 50.5% were males. The MPO level had a significant positive correlation with the SYNTAX score in patients with SYNTAX score >32, r=0.58, p<0.001, and in low SYNTAX score ≤32 patients: r=0.42, p=0.006. Multivariate regression analysis showed that MPO was a significant predictor for SYNTAX score >32 [odds ratio (OR): 1.055, 95% confidence interval (CI): 1.007- 1.101, p=0.009], also age (OR: 1.129, 95% CI: 1.031-1.401, p=0.007), high sensitivity of C-reactive protein (OR: 1.309, 95% CI: 1.167-2.878, p=0.030), and triglycerides (OR: 1.181, 95% CI: 1.077- 1.992, p=0.021) were significant predictors.Conclusions:The elevated MPO levels are related to a higher SYNTAX score and may help predict further STEMI development.
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Kopytsya et al. (2023) conducted a cross-sectional in ST-elevation myocardial infarction (STEMI) (n=93). Myeloperoxidase (MPO) serum levels was evaluated on SYNTAX score >32 (OR 1.055, 95% CI 1.007-1.101, p=0.009). Elevated myeloperoxidase serum levels were a significant predictor for a SYNTAX score >32 in patients with STEMI (OR 1.055; 95% CI 1.007-1.101; p=0.009).
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