Key result
Zuni ancestry is linked to significantly lower intraocular pressure and 0% open-angle glaucoma.
Cross-Sectional (n=405)
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A glaucoma-screening examination was performed on 119 full-blooded Zuni Indians and 286 control subjects who were aged 40 years or older. The mean intraocular pressure (IOP) of the Zuni Indians was significantly lower than that of the control group, adjusted for age and sex differences, in both diabetic and nondiabetic subjects. The control group demonstrated an increasing IOP with age, while the Zunis did not. The prevalence of ocular hypertension was significantly greater in the control group than in the Zunis. The majority of the Zuni subjects with ocular hypertension had diabetes mellitus. None of the Zuni Indians who were screened had primary open-angle glaucoma and none had a family history of glaucoma.
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Kass et al. (1978) conducted a cross-sectional in Intraocular pressure, ocular hypertension, and primary open-angle glaucoma (n=405). Zuni Indian ancestry vs. Non-Zuni control subjects was evaluated on Mean intraocular pressure, prevalence of ocular hypertension, and prevalence of primary open-angle glaucoma. Full-blooded Zuni Indians aged ≥40 years (n=119) had significantly lower mean intraocular pressure and ocular hypertension prevalence than controls (n=286), with 0% primary open-angle glaucoma.
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