Key result
A monocyte to high-density lipoprotein cholesterol ratio >14.57 predicted cardiovascular death or malignant arrhythmic events in patients with hypertrophic cardiomyopathy (72% sensitivity and specificity).
Why the study?
The study was conducted to investigate the impact of the monocyte count to HDL cholesterol ratio on the prognosis of patients with hypertrophic cardiomyopathy.
Does the monocyte to HDL cholesterol ratio predict cardiovascular death or malignant arrhythmic events in patients with hypertrophic cardiomyopathy?
Cohort (n=411)
Does the monocyte to HDL cholesterol ratio predict cardiovascular death or malignant arrhythmic events in patients with hypertrophic cardiomyopathy?
Answers are grounded in this paper and cite their sources.
A higher monocyte to HDL cholesterol ratio is an independent predictor of cardiovascular death and malignant arrhythmias in patients with hypertrophic cardiomyopathy.
Aim: The aim of the study was to investigate the monocyte count to HDL cholesterol ratio (MHR) on the prognosis of patients with hypertrophic cardiomyopathy (HCM). Materials & methods: A total of 411 patients with HCM were assessed. The primary end point was cardiovascular death or malignant arrhythmic events. Results: During the follow-up, primary end point was developed in 54 (13.1%) patients. Receiver operating characteristic (ROC) analysis showed that using a cut-off level of 14.57, MHR predicted the occurrence of primary end point with a sensitivity of 72% and specificity of 72%. In the multivariate model, high MHR was the only significant predictor of the primary end point. Conclusion: This study showed that higher MHR level is an independent predictor of malignant arrhythmia and death in patients with HCM.
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Ekizler et al. (2019) conducted a cohort in Hypertrophic cardiomyopathy (n=411). Monocyte to High-Density Lipoprotein Cholesterol Ratio (MHR) vs. Lower MHR was evaluated on Cardiovascular death or malignant arrhythmic events. A monocyte to high-density lipoprotein cholesterol ratio >14.57 predicted cardiovascular death or malignant arrhythmic events in patients with hypertrophic cardiomyopathy (72% sensitivity and specificity).
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