Key result
Higher monocyte-to-HDL cholesterol ratio (tertile 3 vs 1) was associated with increased all-cause mortality in hypertrophic cardiomyopathy (HR 4.85; 95% CI 2.16-10.89; p<0.001).
Why the study?
Monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has emerged as an indicator for adverse outcomes in cardiovascular diseases, but its relationship with prognosis in hypertrophic cardiomyopathy remains to be evaluated.
Does a higher monocyte-to-HDL cholesterol ratio predict all-cause mortality in Chinese adult patients with hypertrophic cardiomyopathy?
Cohort (n=305)
Does a higher monocyte-to-HDL cholesterol ratio predict all-cause mortality in Chinese adult patients with hypertrophic cardiomyopathy?
Hazard Ratio: 4.85 (95% CI 2.16–10.89)
p-value: p=<0.001
In Chinese adults with hypertrophic cardiomyopathy, a higher monocyte-to-HDL cholesterol ratio is independently associated with increased all-cause mortality.
Higher MHR may support risk stratification in HCM; leaves open whether it improves outcomes or warrants interventions in prospective studies.
OBJECTIVE: A new inflammatory marker, namely monocyte-to-high-density lipoprotein cholesterol ratio (MHR), has emerged as a useful indicator for adverse outcomes in several cardiovascular diseases; however, the relationship between MHR and the prognosis of hypertrophic cardiomyopathy (HCM) remains to be evaluated. We examined the relationship between MHR and all-cause mortality (ACM) in Chinese adult patients with HCM. METHODS: We retrospectively performed clinical evaluation in 305 patients with HCM (median age: 52.0 years, male: 54.10%). RESULTS: During a median follow-up of 4.9 years, ACM occurred in 57 (18.7%) patients. Based on the tertiles of baseline MHR, ACM increased with higher tertile. With tertile 1 as reference, adjusted ACM hazard ratios (HRs) were 2.68 for tertile 2 (95% confidence interval [CI]: 1.18-6.11, p = 0.019) and 4.85 for tertile 3 (95% CI: 2.16-10.89, p < 0.001). Stratified analysis and E-value analysis suggested the robustness of the above-mentioned results. Furthermore, adjusted smooth curve fitting exhibited a non-linear relationship between MHR and ACM (inflection point: 0.5), and the risk of ACM increased significantly with higher MHR only the value below the inflection point (HR: 4.37 per one standard deviation, 95% CI: 1.81-10.6, p = 0.001). Finally, sensitivity analysis was similar to the main findings. CONCLUSION: In Chinese adult patients with HCM, higher MHR is a strong independent predictor of ACM, and a non-linear relationship is also observed between MHR and ACM.
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Li et al. (2023) conducted a cohort in Hypertrophic cardiomyopathy (HCM) (n=305). Monocyte-to-HDL cholesterol ratio (MHR) vs. Tertile 1 (lowest MHR) was evaluated on All-cause mortality (ACM) (HR 4.85, 95% CI 2.16-10.89, p=<0.001). Higher monocyte-to-HDL cholesterol ratio (tertile 3 vs 1) was associated with increased all-cause mortality in hypertrophic cardiomyopathy (HR 4.85; 95% CI 2.16-10.89; p<0.001).
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