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What are the predominant VP4 and VP7 genotypes of human rotavirus in children with diarrhea in the United States?
What are the predominant VP4 and VP7 genotypes of human rotavirus in children with diarrhea in the United States?
P1G1 is the predominant rotavirus strain among children with diarrhea in the US, though P3 genotypes can also cause severe dehydrating diarrhea.
P1G1 predominance informs US rotavirus surveillance; extends genotyping data but leaves open vaccine and severity implications.
The VP4 (P) and VP7 (G) types of 171 rotavirus isolates obtained from children with diarrhea in the United States were characterized by PCR typing assays. Strains P1G1 predominated (71%); this was followed by strains P1G3 (20%) and P2G2 and P1G4 (2% each). Mixed types were identified in five (3%) specimens. Two (1%) strains bearing the P3 genotype (P3G1 and P3G2) were found in children with severe dehydrating diarrhea, although the P3 genotype has been regarded as a possible marker for virus attenuation.
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Santos et al. (1994) studied this question.
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