Why the study?
What is the distribution of G (VP7) and P (VP4) serotypes among human rotaviruses recovered from Japanese children with diarrhea?
What is the distribution of G (VP7) and P (VP4) serotypes among human rotaviruses recovered from Japanese children with diarrhea?
The G1/P8 combination is the most prevalent rotavirus serotype among Japanese children with diarrhea, accounting for 65.2% of cases over a 10-year period.
Informs Japanese rotavirus vaccine strain selection; leaves open need for ongoing serotype surveillance in children.
Both the G (VP7) and P (VP4) serotypes of human rotaviruses collected over a 10-year period from Japanese children with diarrhea were determined by recently-developed polymerase chain reaction-based typing assays. The combination of G1 and P8 was found in 65.2% and the combination of G2 and P4 was found in 15.2%. For the rest of the specimens, only a few other combinations occurred and their relative frequencies were less than 10%. The viruses carrying P9 were always associated with G3 as is the prototype strain AU-1.
No takes yet. Share an insight, caveat, or question.
Kaga et al. (1994) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: