Key result
Human rotavirus VP4 gene alleles from Japanese children with diarrhea showed relative frequencies of 83.1% for Wa, 15.6% for DS-1, 0% for M37, and 1.3% for AU-1.
The Wa allele (serotype P1A) was the most common VP4 gene allele among human rotaviruses in Japanese children with diarrhea between 1982 and 1991.
Wa allele predominance in 1980s-90s Japanese rotavirus cases supports historical strain surveillance; leaves open current genotype distribution for vaccine monitoring.
The relative frequencies of the Wa (corresponding to serotype P1A), DS-1(P1B), M37(P2), and AU-1(P3) alleles of the VP4 gene from rotaviruses collected from the stools of individuals in Japan between 1982 and 1991 were determined to be 83.1, 15.6, 0, and 1.3%, respectively, by a polymerase chain reaction-based typing assay.
No takes yet. Share an insight, caveat, or question.
Gunasena et al. (1993) studied this question. Human rotavirus VP4 gene alleles from Japanese children with diarrhea showed relative frequencies of 83.1% for Wa, 15.6% for DS-1, 0% for M37, and 1.3% for AU-1.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: