Key result
In a cohort of 17 patients with severe hypertriglyceridemia, 76.5% developed acute pancreatitis and 84.2% required ICU admission, with zero mortality observed.
Why the study?
Severe hypertriglyceridemia is linked to serious complications like acute pancreatitis, but its optimal treatment remains a matter of discussion.
Observational (n=17)
No
Severe hypertriglyceridemia is associated with a high rate of acute pancreatitis and ICU admission, but acute management including plasmapheresis and fibrates yields low mortality despite high readmission rates.
INTRODUCTION: Severe hypertriglyceridemia (SHTG) is a rare condition associated with serious complications, such as acute pancreatitis (AP), and the best treatment is still a matter of discussion. The aim of this study is to outline the demographics, management, and outcomes (recurrence and mortality) of complications in patients with SHTG. MATERIAL AND METHODS: of December 2020 in a university hospital. RESULTS: The cohort included 17 patients. The most common complication was AP (13/17 = 76.5%). Admission to the intensive care unit (ICU) was observed in 84.2%. Among patients with AP, the most commonly administered therapies were insulin (82.4%) and fibrates (76.5%). Plasmapheresis was used in 58.8%, and the criteria for using this technique were mainly based on clinical and laboratory abnormalities. There were no deaths. The readmission rate at 30 days was 36.3%. CONCLUSION: This study shows the morbidity profile associated with SHTG, with a high level of ICU admissions and also a high level of the use of plasmapheresis. In our population, this approach had good results, and this should be highlighted as there are no clear international guidelines for this intervention. Distinguishing between patients with familial chylomicronemia syndrome or with multifactorial chylomicronemia is important as recent specific therapy for lipoprotein lipase (LPL) genetic deficit is available. In the near future, the performance of a genetic study should be considered in patients with SHTG as an attempt to avoid the high recurrence rate of complications of this disease.
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Laranjeira et al. (2023) conducted an observational in Severe hypertriglyceridemia (n=17). Severe hypertriglyceridemia was evaluated on Incidence of acute pancreatitis. In a cohort of 17 patients with severe hypertriglyceridemia, 76.5% developed acute pancreatitis and 84.2% required ICU admission, with zero mortality observed.
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