Key result
SSRI use is associated with roughly doubled odds of upper gastrointestinal bleeding, though the absolute risk remains low.
Why the study?
Does the use of SSRIs increase the risk of abnormal bleeding and decrease the risk of ischemic heart disease events?
Population
Patients using selective serotonin reuptake inhibitors (SSRIs)
Design
Review
Authors
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May warrant gastroprotection assessment in high-risk patients on SSRIs; leaves open net cardiovascular effects pending prospective trials.
Does the use of SSRIs increase the risk of abnormal bleeding and decrease the risk of ischemic heart disease events?
Effect estimate: roughly doubled odds
SSRIs are associated with an increased risk of upper gastrointestinal bleeding, especially when combined with NSAIDs or antiplatelets, but may offer a protective effect against ischemic heart disease events.
Andrade et al. (2010) conducted a review in Abnormal bleeding. Selective serotonin reuptake inhibitors (SSRIs) was evaluated on Upper gastrointestinal (GI) bleeding (roughly doubled odds). SSRI use is associated with roughly doubled odds of upper gastrointestinal bleeding, though the absolute risk remains low.
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