Key result
V122I transthyretin variant linked to ~86% higher atrial fibrillation risk in Black Americans.
Cohort (n=3,856)
Yes
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“The hereditary form of transthyretin amyloid is generally rare. However, we know that approximately 4% of the black population in the U.S. carries the gene. Not all of these people develop amyloidosis, but this is a huge population at risk.”
Cohort study reveals increased risks of atrial fibrillation and ischemic stroke in Black Americans carrying the V122I transthyretin variant, indicating underappreciated vascular manifestations.
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Selvaraj et al. (2021) conducted a cohort in Atrial fibrillation and ischemic stroke risk (n=3,856). V122I TTR variant vs. Non-carriers of V122I TTR variant was evaluated on Atrial fibrillation (HR 1.86, 95% CI 1.26, 2.74, p=0.002). Among Black Americans, carrying the V122I transthyretin variant significantly increased the risk of atrial fibrillation (HR 1.86) and ischemic stroke (HR 1.58) over 23 years of follow-up.
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