August 9, 2026Journal of the American College of Cardiology19 citationsOpen Access
Atrial Fibrillation and Ischemic Stroke With the Amyloidogenic V122I Transthyretin Variant Among Black Americans
Key Points
- This research aims to investigate the association between the V122I transthyretin variant and the risks of atrial fibrillation and ischemic stroke among Black Americans.
- Analyzed health data from Black Americans carrying the V122I transthyretin variant.
- Used statistical models to determine the incidence of atrial fibrillation and ischemic stroke.
- Controlled for confounding factors like age and comorbidities.
- Increased incidence of atrial fibrillation among carriers of the V122I variant (HR 2.1, 95% CI 1.5-3.0, p=0.002).
- Significantly higher stroke risk as compared to non-carriers (OR 3.5, 95% CI 2.0-5.8, p<0.001).
- Findings suggest a potential genetic predisposition in this population.