What question did this study set out to answer?

To review the clinical characteristics, diagnostic evaluation methods, and cognitive and psychiatric manifestations associated with multiple sclerosis.

October 29, 1999Philosophical Transactions of the Royal Society B Biological SciencesOpen Access

Multiple sclerosis⋮ the disease and its manifestations

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Authors

WMW. I. McDonaldTulane University MRMaría A. RonUniversity of London

Discussion

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Implication

Clinical review demonstrates clinical progression and cognitive deficits in multiple sclerosis, highlighting the diagnostic value of magnetic resonance imaging.

Key Points

To review the clinical characteristics, diagnostic evaluation methods, and cognitive and psychiatric manifestations associated with multiple sclerosis.
Synthesized clinical patterns of relapse, remission, and progression across multiple sclerosis disease stages.
Evaluated diagnostic findings from magnetic resonance imaging, evoked potentials, and cerebrospinal fluid testing for oligoclonal IgG.
Early episodes such as optic neuritis typically resolve over two to three months with near-complete recovery, but persistent neurophysiological and structural abnormalities remain detectable.
Cognitive deficits in attention, memory, and executive skills correlate with cerebral white matter lesion burden on magnetic resonance imaging.
Depression and anxiety correlate poorly with magnetic resonance imaging lesion load, whereas uncommon symptoms like psychosis, euphoria, and emotional lability show strong anatomical correlation.

Cite This Study

McDonald et al. (1999) studied this question.

synapsesocial.com/papers/6a786dfb2e130d02afed2440 https://doi.org/10.1098/rstb.1999.0506

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Implication

Clinical review demonstrates clinical progression and cognitive deficits in multiple sclerosis, highlighting the diagnostic value of magnetic resonance imaging.

Multiple sclerosis⋮ the disease and its manifestations

Discussion

Member takes

Implication

Key Points

Cite This Study

Multiple sclerosis⋮ the disease and its manifestations

Discussion

Member takes

Implication

Key Points

Cite This Study

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