Key result
Natriuretic peptides induce lipolysis, increase lipid oxidation rates, and affect adipokine production, which may be relevant in physical exercise, congestive heart failure, and obesity.
Natriuretic peptides play a role in metabolic regulation by inducing lipolysis and affecting adipokine production, which may be relevant in conditions such as heart failure and obesity.
Supports exploring natriuretic peptide metabolic effects in HF and obesity; leaves open whether targeting them improves outcomes.
In addition to their well-established effects on blood pressure and volume homeostasis, natriuretic peptides have complex effects on carbohydrate and lipid metabolism. In vivo, pharmacological and physiological concentrations of atrial natriuretic peptides induce lipolysis in a concentration-dependent manner and increase the lipid oxidation rate. The response appears to be mediated through the stimulation of natriuretic peptide receptor-A. More recent studies suggest that natriuretic peptides also affect the production of several adipokines. These mechanisms may be relevant, as natriuretic peptide availability is altered in numerous physiological and pathological conditions, including physical exercise, congestive heart failure and obesity.
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Birkenfeld et al. (2007) conducted a review in Metabolic regulation. Natriuretic peptides was evaluated. Natriuretic peptides induce lipolysis, increase lipid oxidation rates, and affect adipokine production, which may be relevant in physical exercise, congestive heart failure, and obesity.
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