Metabolic disease and cardiovascular risk in people treated with antipsychotics in the community
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Key result
People with severe mental illness treated with antipsychotics had a significantly higher prevalence of metabolic syndrome compared to matched controls (OR 3.68).
Why the study?
Does antipsychotic treatment increase the prevalence of metabolic syndrome and cardiovascular risk in people with severe mental illness compared to healthy controls?
Population
90 people with severe mental illness treated with antipsychotics in the community for a minimum of 6 months…
Comparison
Antipsychotic medication for a minimum of 6… vs 92 age- and gender-matched controls with no…
Design
Case-control
Authors
Discussion
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Implication
Supports routine metabolic screening in SMI on antipsychotics; leaves open causal contribution of treatment versus illness factors.
Study Design
Type
Case-Control (n=182)
Structured PICO
Does antipsychotic treatment increase the prevalence of metabolic syndrome and cardiovascular risk in people with severe mental illness compared to healthy controls?
P
Population
182 participants, comprising 90 adults with severe mental illness treated with antipsychotics for at least 6 months and 92 age- and gender-matched healthy controls.
E
Exposure
Antipsychotic medication (77.5% atypical, 22.5% typical) for a minimum of 6 months.
C
Comparator
92 age- and gender-matched controls with no history of psychiatric disorder or psychiatric medication.
O
Outcome
Prevalence of metabolic syndrome and 10-year cardiovascular risk (JBS and Framingham definitions).surrogate
Main Result
Odds Ratio: 3.68 (95% CI 1.71–7.93)
Absolute Event Rate: 33.3% vs 11.9%
p-value: p=0.001
People with severe mental illness treated with antipsychotics in the community have a significantly higher prevalence of metabolic syndrome and elevated 10-year cardiovascular risk compared to matched controls.
Limitations
- Not designed or powered to investigate the contribution of specific antipsychotic drugs or classes of drugs to metabolic or cardiovascular disease
- Small sample of patients not currently receiving antipsychotics had previously been prescribed them, potentially confounding results
Cite This Study
Mackin et al. (2007) conducted a case-control in Severe mental illness (n=182). Antipsychotic treatment vs. Age- and gender-matched healthy controls was evaluated on Prevalence of metabolic syndrome (OR 3.68, 95% CI 1.71-7.93, p=0.001). People with severe mental illness treated with antipsychotics had a significantly higher prevalence of metabolic syndrome compared to matched controls (OR 3.68).
Topics
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