Population
32 subjects, comprising 18 patients with heart failure with preserved ejection fraction and 14 healthy…
Design
Case-control
Key result
Patients with HFpEF exhibited significantly decreased peak VO2 (12.0 vs 19.1 mL/min/kg, P<0.001) and elevated inflammatory and oxidative stress biomarkers compared with healthy controls.
Authors
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Inflammation may contribute to HFpEF exercise intolerance; hypothesis-generating and should not yet change practice.
Observational (n=32)
Absolute Event Rate: 12% vs 19.1%
p-value: p=<0.001
Patients with HFpEF demonstrate significantly reduced cardiopulmonary reserve and elevated inflammatory and oxidative stress biomarkers compared to healthy controls, despite similar peripheral arterial blood flow.
Vitiello et al. (2014) conducted an observational in Heart failure with preserved ejection fraction (n=32). Heart failure with preserved ejection fraction vs. Healthy subjects was evaluated on Peak VO2 (mL/min/kg) (p=<0.001). Patients with HFpEF exhibited significantly decreased peak VO2 (12.0 vs 19.1 mL/min/kg, P<0.001) and elevated inflammatory and oxidative stress biomarkers compared with healthy controls.