Why the study?
Systemic inflammation in HFpEF predicts worse outcomes, but its impact on exercise haemodynamics in patients with unexplained dyspnoea required investigation.
Does systemic inflammation impact exercise haemodynamics and capacity in patients with unexplained dyspnoea and HFpEF?
Population
191 consecutively evaluated subjects referred for unexplained dyspnoea
Comparison
Systemic inflammation (hs-CRP ≥2 mg/L) vs no systemic inflammation
Design
Prospective cohort study
Key result
In subjects with unexplained dyspnoea, systemic inflammation was associated with lower peak oxygen consumption (16.9 vs. 20.6 mL/min/kg; p<0.001) and impaired right ventricular reserve.
Authors
Loading...
Suggests an inflammatory phenotype drives exertional intolerance in HFpEF; leaves open.
Cohort (n=191)
No
Does systemic inflammation impact exercise haemodynamics and capacity in patients with unexplained dyspnoea and HFpEF?
Absolute Event Rate: 16.9% vs 20.6%
p-value: p=<0.001
In patients with unexplained dyspnoea, systemic inflammation is associated with reduced exercise capacity and impaired right ventricular contractile reserve.
Mondellini et al. (2026) conducted a cohort in Unexplained dyspnoea and heart failure with preserved ejection fraction (n=191). Systemic inflammation (hs-CRP ≥2 mg/L) vs. Without systemic inflammation was evaluated on Peak oxygen consumption (mL/min/kg) (p=<0.001). In subjects with unexplained dyspnoea, systemic inflammation was associated with lower peak oxygen consumption (16.9 vs. 20.6 mL/min/kg; p<0.001) and impaired right ventricular reserve.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: