Key result
MV-Ao and SVC-Ao Doppler methods predicted postnatal first-degree AV block with high sensitivity (91.7%) and AUC (0.87 and 0.89, P<0.001), but positive predictive values were only 42.3% and 47.8%.
Why the study?
Do Doppler-derived AV time intervals accurately predict postnatal first-degree atrioventricular block in fetuses of anti-SSA/Ro positive mothers?
Population
95 fetuses of anti-SSA/Ro positive mothers undergoing weekly fetal echocardiograms at 18-24 weeks' gestation
Comparison
Doppler-derived atrioventricular time intervals… vs Postnatal electrocardiography (PR interval)
Design
Cohort
Follow-up
Until birth (postnatal)
Authors
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High sensitivity may reassure against conduction block in anti-SSA/Ro fetuses; leaves open prospective validation given modest PPV.
Observational (n=95)
Do Doppler-derived AV time intervals accurately predict postnatal first-degree atrioventricular block in fetuses of anti-SSA/Ro positive mothers?
Effect estimate: AUC 0.87 and 0.89
p-value: p=< 0.001
MV-Ao and SVC-Ao Doppler methods are highly sensitive for predicting postnatal first-degree AV block in at-risk fetuses and can reliably exclude conduction disturbances, though they are limited by a positive predictive value of approximately 50%.
Bergman et al. (2009) conducted an observational in Fetuses at risk for atrioventricular block (n=95). Doppler flow echocardiography (MV-Ao and SVC-Ao time intervals) vs. MV time intervals was evaluated on Postnatal first-degree atrioventricular (AV) block (AUC 0.87 and 0.89, p=< 0.001). MV-Ao and SVC-Ao Doppler methods predicted postnatal first-degree AV block with high sensitivity (91.7%) and AUC (0.87 and 0.89, P<0.001), but positive predictive values were only 42.3% and 47.8%.
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