Key result
Brachial-ankle pulse wave velocity was an independent risk factor for waist circumference, BMI, body fat rate, and body fat volume (P < .001 for all), largely mediated by blood pressure.
Why the study?
Although baPWV is linked to cardiovascular disease and obesity, whether BMI is associated with baPWV remains controversial.
Is brachial-ankle pulse wave velocity associated with body fat indicators in healthy participants?
Observational (n=429)
Is brachial-ankle pulse wave velocity associated with body fat indicators in healthy participants?
Effect estimate: exp(β) = 1.011, 1.004, 1.010, and 1.009 respectively
p-value: p=<.001
Brachial-ankle pulse wave velocity is independently associated with body fat indices, an effect that is largely mediated by systolic and diastolic blood pressure.
baPWV was associated with adiposity measures; leaves open whether it adds value beyond BMI for CV risk stratification in observational cohorts.
Background Brachial-ankle pulse wave velocity (baPWV) is an important clinical indicator of aortic stiffness and a risk predictor of cardiovascular disease and associated with obesity. However, whether body mass index (BMI) is associated with baPWV remains controversial. In our study, body fat-related indicators, including BMI, body fat rate (BFR), body fat volume (BFV), waist circumference (WC) were examined from healthy volunteers. We investigated the correlation of baPWV with these indicators and also assessed whether baPWV has the potential to predict these indicators.Methods A total of 429 healthy participants were enrolled in this study. Body fat indices, blood pressures, baPWV and blood metabolic indices were measured and recorded. The association of baPWV and indices reflecting body fat and blood pressure, as well as mediation effect were analyzed.Results Three different types of baPWV values were significantly correlated. Mean level of baPWV was an independent risk factor for WC, BMI, BFR, and BFV (exp(β) = 1.011, 1.004, 1.010 and 1.009, respectively, P < .001 for all) but not BMR. As for mediation effects, baPWV positively influenced WC (Total effect = 0.011, P < .001), BMI (Total effect = 0.004, P < .001) and BFV (Total effect = 0.009, P < .001) in indirect way mediated by SBP and DBP, while baPWV influenced BFR in both direct (Effect = 0.004, P = .018) and indirect way.Conclusions Levels of baPWV correlated with obesity and is an independent risk factor for WC, BMI, BFR and BFV. Besides, baPWV positively associated with WC, BMI and BFV mainly in indirect way mediated by SBP and DBP, and baPWV associated with BFR in both direct and indirect way.
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Wang et al. (2023) conducted an observational in Healthy (n=429). Brachial-ankle pulse wave velocity (baPWV) was evaluated on Waist circumference (WC), BMI, body fat rate (BFR), and body fat volume (BFV) (exp(β) = 1.011, 1.004, 1.010, and 1.009 respectively, p=<.001). Brachial-ankle pulse wave velocity was an independent risk factor for waist circumference, BMI, body fat rate, and body fat volume (P < .001 for all), largely mediated by blood pressure.
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