Key result
In rats, the local renal aldosterone system is physiologically active and CYP11B2 expression is modulated by angiotensin II, low salt intake, glucose, insulin, and AT1 receptors.
Population
Normal, adrenalectomized, or streptozotocin-induced insulin-deficient diabetic hyperglycemic rats
Comparison
Low salt intake, angiotensin II, valsartan, or… vs Untreated or normal conditions
Design
Preclinical
Authors
Loading...
Should not change clinical practice; leaves open the role of local renal aldosterone in human hypertension and diabetes.
This study demonstrates the existence of a physiologically active local renal aldosterone system that is modulated by salt, angiotensin II, and diabetes.
Xue et al. (2005) studied Normal, adrenalectomized, or streptozotocin-induced insulin-deficient diabetic hyperglycemia. Low salt intake, angiotensin II, valsartan, and insulin was evaluated on Renal CYP11B2 mRNA and protein and aldosterone production. In rats, the local renal aldosterone system is physiologically active and CYP11B2 expression is modulated by angiotensin II, low salt intake, glucose, insulin, and AT1 receptors.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: