Key result
Type 2 diabetes mellitus was associated with significantly higher diastolic dysfunction compared with healthy controls (P <0.05).
Why the study?
Given high rates of diabetes in Saudi Arabia and heart failure in diabetic patients, echocardiographic changes in Saudi patients with type 2 diabetes compared with healthy controls needed assessment.
Does Type 2 Diabetes Mellitus affect echocardiographic parameters and diastolic function in Saudi patients compared to healthy controls?
Case-Control (n=160)
No
Does Type 2 Diabetes Mellitus affect echocardiographic parameters and diastolic function in Saudi patients compared to healthy controls?
p-value: p=<0.05
Type 2 diabetes mellitus is associated with a significantly higher prevalence of diastolic dysfunction in Saudi patients, independent of other structural echocardiographic changes.
May identify subclinical changes in Saudi T2DM; hypothesis-generating and leaves open need for prospective validation.
Background and Objectives: Cardiovascular disease is one of the leading causes of morbidity and mortality among the diabetic population. Given the high prevalence of diabetes mellitus (DM) in Saudi Arabia and the high prevalence of heart failure in the diabetic population, this study assesses the echocardiographic changes in Saudi patients with type 2 DM (T2DM) compared with healthy controls. Materials and Methods: In this retrospective case control study, 80 patients with diabetes (45 males, age: 58.78±10.2 years) were compared with 80 controls (45 males, age: 58.6±10 years) who underwent an echocardiographic study in the King Saud University Medical City, Riyadh, Saudi Arabia. Results: There were no significant differences between patients with diabetes and controls in terms of aortic root diameter, left atrium diameter, posterior wall, interventricular wall thickness, left ventricular diameters and ejection fraction. However, diastolic dysfunction was statistically significantly higher in the diabetic group compared with the control group (P <0.05). Conclusions: This is the first case control study in Saudi Arabia that assesses echocardiographic parameters in T2DM patients. DM is an independent risk factor for diastolic dysfunction regardless of its association with hypertension and dyslipidemia.
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Almigbal et al. (2023) conducted a case-control in Type 2 Diabetes Mellitus (n=160). Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Diastolic dysfunction (p=<0.05). Type 2 diabetes mellitus was associated with significantly higher diastolic dysfunction compared with healthy controls (P <0.05).
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