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The use of extradural (epidural) steroids in the management of selected cases of lumbosciatic syndrome is well known. This paper reports the appearance of systemic side-effects in four cases after each had received an injection of 6-10 ml of methylprednisolone and 0.25% bupivacaine into the extradural space at the site nearest to the affected nerve roots.
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Knight et al. (1980) studied this question.
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